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Isopropanol → Ethyl cis-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate

HRID 1748261
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HRID 1748261 반응식
[CH3:1][C@H:2]1[C@@H:17]([CH3:18])[N:6]2[C:7]3[CH:8]=[C:9]([C:14]([OH:16])=[O:15])[CH:10]=[CH:11][C:12]=3[CH:13]=[C:5]2[C:4](=[O:19])[NH:3]1.[CH:20](O)(C)[CH3:21]>CCCCCCC>[CH3:1][C@H:2]1[C@@H:17]([CH3:18])[N:6]2[C:7]3[CH:8]=[C:9]([C:14]([O:16][CH2:20][CH3:21])=[O:15])[CH:10]=[CH:11][C:12]=3[CH:13]=[C:5]2[C:4](=[O:19])[NH:3]1.[CH3:1][C@@H:2]1[C@H:17]([CH3:18])[N:6]2[C:7]3[CH:8]=[C:9]([C:14]([O:16][CH2:20][CH3:21])=[O:15])[CH:10]=[CH:11][C:12]=3[CH:13]=[C:5]2[C:4](=[O:19])[NH:3]1
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반응물 2

HCID 3776IsopropanolHCID 67234926(3S,4R)-3,4-Dimethyl-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-7-carboxylic acid2회

생성물 2

HCID 67234919ethyl (3R,4S)-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate수율 45%HCID 67235475Ethyl cis-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate수율 46%

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

Racemic cis-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylic acid (Intermediate F, 1.9 g, 6.7 mmol) is separated on a preparative chiral column (Chiralpak AD, 5 cm×50 cm, 20 u, Chiral Technologies, West Chester, Pa.) using Gilson preparative HPLC (Mobile Phase: 12% isopropanol in heptane; Flow rate: 100 mL/min) to afford ethyl (3S,4R)-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate (870 mg, 46%) and ethyl (3R,4S)-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate (852 mg, 45%).

출처 및 근거

ORD 기록
ord-41ada2b325894882813051d129af0f33
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09150577B2

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