Benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate → 5-Tert-butyl-1,3-oxazol-2-amine

HRID 1748331노트

반응식

HRID 1748331 반응식
[C:1]([C:5]1[O:9][C:8]([NH:10]C(=O)OCC2C=CC=CC=2)=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[O:9][C:8]([NH2:10])=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 14054539Benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate

생성물 1

HCID 146232945-Tert-butyl-1,3-oxazol-2-amine수율 68%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate (5.0 g, 18.2 mmol) in methanol (100 mL) is added 10% palladium on carbon (500 mg, 0.5 mmol). The reaction is stirred at room temperature for 3 h under hydrogen atmosphere. The reaction mixture is filtered through Celite and the filtrate is concentrated. The residue is purified by flash column chromatography to afford the title compound (1.7 g, 68%) as a light brown solid.

후처리

  1. filtrationThe reaction mixture is filtered through Celite
  2. concentrationthe filtrate is concentrated
  3. customThe residue is purified by flash column chromatography

출처 및 근거

ORD 기록
ord-c8351d8a8e604ec1911bc060e66eade0
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150577B2

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