Ethyl 1-(5-bromopyridin-2-yl)-5-methylpyrazole-4-carboxylate → 1-(5-Ethyl-6-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid
반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[CH:17]=[CH:16][C:15](I)=[C:14]([CH3:19])[N:13]=2)[C:10]=1[CH3:11])=[O:5])C.[CH2:20](OC(C1C=NN(C2C=CC(Br)=CN=2)C=1C)=O)[CH3:21]>>[CH2:20]([C:15]1[CH:16]=[CH:17][C:12]([N:9]2[C:10]([CH3:11])=[C:6]([C:4]([OH:3])=[O:5])[CH:7]=[N:8]2)=[N:13][C:14]=1[CH3:19])[CH3:21]참가 물질
3
실험 절차
1-(5-Iodo-6-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester described n Reference Example 31 was used in place of 1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester in Reference Example 28, and reacted and treated in a similar manner to give the titled compound.
후처리
- customreacted
- additiontreated in a similar manner
출처 및 근거
- ORD 기록
- ord-bf5a7cd68f734a0289ea6c9a5d43d1d3
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09150555B2
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