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Water → 1-[5-(Difluoromethyl)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid

HRID 1748478
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반응식

HRID 1748478 반응식
FC(F)(F)C(O)=O.C([O:12][C:13]([C:15]1[CH:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([CH:26]([F:28])[F:27])=[CH:22][N:21]=2)[CH:16]=1)=[O:14])(C)(C)C.O>O1CCCC1>[F:28][CH:26]([F:27])[C:23]1[CH:24]=[CH:25][C:20]([N:17]2[CH:18]=[CH:19][C:15]([C:13]([OH:14])=[O:12])=[CH:16]2)=[N:21][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 866924421-[5-(difluoromethyl)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid tert-butyl ester

생성물 1

HCID 866924431-[5-(Difluoromethyl)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid수율 96.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트

Trifluoroacetic acid (13.6 ml) was added at room temperature to a solution of 1-[5-(difluoromethyl)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid tert-butyl ester (1.01 g) in tetrahydrofuran (3.4 ml) and stirred at the same temperature for an hour. After completion of the reaction, water was added to the reaction solution and the precipitated solid was collected by filtration to give the titled compound (790 mg) as a white solid.

후처리

  1. additionwas added to the reaction solution
  2. filtrationthe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-7eef64daee5e4879abc000d4a7a16e6c
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09150555B2

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