Water → 1-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid

HRID 1748485노트

반응식

HRID 1748485 반응식
FC(F)(F)C(O)=O.C([O:12][C:13]([C:15]1[CH:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][N:21]=2)[CH:16]=1)=[O:14])(C)(C)C.O>ClCCl>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([N:17]2[CH:18]=[CH:19][C:15]([C:13]([OH:14])=[O:12])=[CH:16]2)=[N:21][CH:22]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 866924471-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid tert-butyl ester

생성물 1

HCID 866924481-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid수율 97%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (3 ml) was added to a solution of 1-(5-chloropyridin-2-yl)pyrrole-3-carboxylic acid tert-butyl ester (1.0 g) in dichloromethane (10 ml) and stirred at room temperature for four hours. Water was added to the reaction solution and the precipitated solid was washed with water to give the titled compound (775 mg) as a gray solid.

후처리

  1. washthe precipitated solid was washed with water

출처 및 근거

ORD 기록
ord-7bd8f627acfb4b40a3a5b55cea1781c8
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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