Tetrahydro-2,5-dimethoxyfuran-3-carbaldehyde → 1-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

HRID 1748486노트

반응식

HRID 1748486 반응식
CO[CH:3]1[CH:7]([CH:8]=[O:9])[CH2:6][CH:5](OC)O1.Cl.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>O>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH:5]=[CH:6][C:7]([CH:8]=[O:9])=[CH:3]2)=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 567310Tetrahydro-2,5-dimethoxyfuran-3-carbaldehydeHCID 27349564-Anisidine hydrochloride

생성물 1

HCID 105599931-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

2,5-Dimethoxytetrahydrofuran-3-carbaldehyde (7.31 g) and p-anisidine hydrochloride (7.28 g) were added to water (100 ml) and stirred at 60° C. for three hours. The precipitated yellow solid were filtered at the same temperature, washed with water (50 ml), saturated aqueous solution of sodium bicarbonate (50 ml), and further water (50 ml) to give 1-(4-methoxyphenyl)pyrrole-3-carb aldehyde.

후처리

  1. filtrationThe precipitated yellow solid were filtered at the same temperature
  2. washwashed with water (50 ml), saturated aqueous solution of sodium bicarbonate (50 ml), and further water (50 ml)

출처 및 근거

ORD 기록
ord-88551588a76e48aaa70c5b1b9d121d31
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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