1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid → 5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

HRID 1748598노트

반응식

HRID 1748598 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=[N:9]2)=[N:6][CH:7]=1>CN(C)C=O.[C].[Pd]>[CH3:13][C:12]1[N:8]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:7][N:6]=2)[N:9]=[CH:10][C:11]=1[C:14]([OH:16])=[O:15]

참가 물질

4

반응물 1

HCID 653475861-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid

생성물 1

HCID 167776245-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid수율 106.4%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid (30 mg) described in Reference Example 24 in N,N-dimethylformamide (1 ml) was added 10% palladium carbon (containing about 50% water) (10 mg) at room temperature, and stirred at the same temperature for 30 minutes under hydrogen atmosphere. After completion of the reaction, the reaction solution was filtered through Celite, then the solvent was evaporated in vacuo, azeotropically concentrated together with toluene to give the titled compound (23 mg) as a white solid.

후처리

  1. customAfter completion of the reaction
  2. filtrationthe reaction solution was filtered through Celite
  3. customthe solvent was evaporated in vacuo
  4. concentrationazeotropically concentrated together with toluene

출처 및 근거

ORD 기록
ord-3282666ea7814e558169ab2525ffbf40
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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