Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1748610생성일: 2026년 10월 26일
Dimethylformamide → 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride
https://huagongshe.com/reaction/1748610
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 5-methyl-1-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazole-4-carboxylic acid | HCID 16227845 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride | HCID 89734997 | — |
반응 단계
To a solution of 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid (40.0 g) described in Reference Example 8 in toluene (147 ml) were added N,N-dimethylformamide (catalyst quantity) and thionyl chloride (52.6 g) at room temperature, and stirred at 80° C. for 4.5 hours. After completion of the reaction, the solvent and excessive thionyl chloride were evaporated, azeotropy was performed with toluene twice, and then dried in vacuo to give the titled compound as a pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09150555B2 |
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| 출처 데이터셋 | uspto-grants-2015_10 |
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| ORD ID | ord-5ee31dcb134e4a2ab06647809297759a |
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| 출처 메모 | uspto-grants-2015_10 |
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