3-Bromo-4-hydroxybenzaldehyde → 2-Bromo-4-(5-(trifluoromethyl)-2,3-dihydrobenzo[d]thiazol-2-yl)phenol

참여 물질

역할	이름	HCID	투입량
반응물	3-Bromo-4-hydroxybenzaldehyde	HCID 76308	—
반응물	2-Amino-4-(trifluoromethyl)benzenethiol	HCID 88042	—
용매	Dimethylformamide	HCID 6228	—
생성물	2-Bromo-4-(5-(trifluoromethyl)-2,3-dihydrobenzo[d]thiazol-2-yl)phenol	HCID 60194686	10.5%

반응 조건

온도	100 °C

반응 단계

In a DMF (3 mL) solvent, a solution including 2-amino-4-trifluoromethylbenzenethiol (100 mg, 0.44 mmol) and 3-bromo-4-hydroxybenzaldehyde (88.4 mg, 0.44 mmol) was heated at a temperature of 100° C. for 2.5 hours. After DMF was evaporated, the residual was distributed between methylene chloride and water, and an organic layer was evaporated. The produced solid was filtered, and washed with ethyl acetate to obtain a solid Compound 119.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09155690B2
출처 데이터셋	uspto-grants-2015_10
ORD ID	ord-46b0224d80724a758a90847126765465
출처 메모	uspto-grants-2015_10