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1-benzyl-N-methylpiperidin-4-amine → N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide

HRID 1749304
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HRID 1749304 반응식
CC1C=C(C)N=C(OCC(O)=O)N=1.C(N1CCC(NC)CC1)C1C=CC=CC=1.[CH2:29]([N:36]1[CH2:41][CH2:40][CH:39]([N:42]([CH3:55])[C:43](=[O:54])[CH2:44][O:45][C:46]2[N:51]=[C:50]([CH3:52])[CH:49]=[C:48]([CH3:53])[N:47]=2)[CH2:38][CH2:37]1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[ClH:56].C(OCC)(=O)C>CO>[CH2:29]([N:36]1[CH2:41][CH2:40][CH:39]([N:42]([CH3:55])[C:43](=[O:54])[CH2:44][O:45][C:46]2[N:51]=[C:50]([CH3:52])[CH:49]=[C:48]([CH3:53])[N:47]=2)[CH2:38][CH2:37]1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1.[ClH:56].[CH2:29]([N:36]1[CH2:41][CH2:40][CH:39]([N:42]([CH3:55])[C:43](=[O:54])[CH2:44][O:45][C:46]2[N:51]=[C:50]([CH3:52])[CH:49]=[C:48]([CH3:53])[N:47]=2)[CH2:38][CH2:37]1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 41361281-benzyl-N-methylpiperidin-4-amineHCID 198818052-((4,6-Dimethylpyrimidin-2-yl)oxy)acetic acidHCID 21866389Hydrogen chloride-ethyl acetateHCID 59336186N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide

생성물 2

HCID 59336186N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide수율 62%
HCID 68416141N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide (147 mg: 62% yield) was synthesized from 2-(4,6-dimethylpyrimidine-2-yl)oxyacetic acid (117 mg) and 1-benzyl-N-methylpiperidine-4-amine (131 mg) in the same manner as in Example 49. Then, to a methanol solution of N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide, 1 equivalent of 4N HCl/ethyl acetate solution was added. The mixture was then concentrated under reduced pressure to give the desired product as a white amorphous.

후처리

  1. concentrationThe mixture was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-958769acabf84a1b8029a01fb893427a
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09156817B2

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