Trifluoroacetic acid → 3-(2-Aminoethyl)-5-chloropyridine 1-oxide

HRID 1749470노트

반응식

HRID 1749470 반응식
C(OC([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[N+:13]([O-:18])[CH:14]=[C:15]([Cl:17])[CH:16]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[N+:13]([O-:18])[CH:14]=[C:15]([Cl:17])[CH:16]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 1181621543-(2-((tert-Butoxycarbonyl)amino)ethyl)-5-chloropyridine 1-oxide

생성물 1

HCID 1181621313-(2-Aminoethyl)-5-chloropyridine 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-(2-((tert-butoxycarbonyl)amino)ethyl)-5-chloropyridine 1-oxide (90 mg, crude) in DCM (3 mL) was added TFA (1.5 mL) at 0° C. The resulting reaction mixture was stirred at room temperature for 1.5 h. The reaction mixture was concentrated to afford the crude title product, which was used directly in the next step without further purification (80 mg, crude). MS (ESI) m/z 173.1 [M+H]+.

후처리

  1. customThe resulting reaction mixture
  2. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-dbeae91f70fa424f9520f5e46384c33f
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156798B2

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