Trifluoroacetic acid → 1-(2-Amino-ethyl)-3-methyl-1,3-dihydro-benzoimidazol-2-one
반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH2:11][CH2:12][NH:13]C(=O)OC(C)(C)C)[C:3]1=[O:21].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:13][CH2:12][CH2:11][N:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:2]([CH3:1])[C:3]1=[O:21]참가 물질
4
실험 절차
To a solution of tert-butyl (2-(3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethyl)carbamate (100 mg, 0.345 mmol) in DCM (3 mL) was added TFA (1.5 mL) at 0° C. to 5° C. The resulting reaction mixture was stirred at room temperature for 2 h. The reaction mixture was concentrated to give the crude product, which was used in the next step without further purification (140 mg crude). MS (ESI) m/z 192.1 [M+H]+.
후처리
- customThe resulting reaction mixture
- concentrationThe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-eb1a1ceb073248e6aad32d4a5f031b48
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156798B2
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