참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 6-Fluoro-1H-indole-3-ethylamine monohydrochloride | HCID 3085078 | — |
| 생성물 | HCID 118162198 | HCID 118162198 | 47% |
반응 단계
To a solution of 2-(6-fluoro-1H-indol-3-yl)ethanamine hydrochloride (500 mg, 2.3 mmol) in DMSO (0.8 mL) was added hydrochloric acid (36%, 1.3 g, 12.8 mmol). The resulting reaction mixture was stirred at 50° C. in a sealed tube for 6 h. After cooling to room temperature, the reaction mixture was filtered. The resulting cake was stirred in EtOH (5 mL). The mixture was filtered and dried to give the desired product (250 mg, 1.28 mmol, 47% yield) as a yellow solid. MS (ESI) m/z 195.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09156798B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_10 |
|---|
| ORD ID | ord-02d7faa9def14b0a8852b78dc2eb5fce |
|---|
| 출처 메모 | uspto-grants-2015_10 |
|---|
