참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 6-Hydroxy-3-coumaranone | HCID 235717 | — |
| 반응물 | 5-nitro-1H-indole-3-carbaldehyde | HCID 246039 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (Z)-6-hydroxy-2-[(5-nitro-1H-indol-3-yl)methylene]benzofuran-3(2H)-one | HCID 71278726 | 90% |
반응 단계
A solution of 6-hydroxybenzofuran-3(2H)-one (0.400 g, 2.7 mmol) and 5-nitro-1H-indole-3-carboxaldehyde (0.56 g, 2.9 mmol) in ethanol (5.0 mL) was added with concentrated hydrochloric acid (1.0 mL), and the mixture was stirred at 70° C. for 3 hours. The reaction mixture was cooled to room temperature, and then the solid was collected by filtration, and washed with methanol to obtain (Z)-6-hydroxy-2-[(5-nitro-1H-indol-3-yl)methylene]benzofuran-3(2H)-one (0.77 g, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09156827B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_10 |
|---|
| ORD ID | ord-b2c8dc259b0445cdaa3f7d4d335e0ba9 |
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| 출처 메모 | uspto-grants-2015_10 |
|---|
