Acetic Acid → 6-nitro-1H-indole-3-carbaldehyde

HRID 1749748

반응식

HRID 1749748 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:13](O)(=[O:15])C.C1N2CN3CN(C2)CN1C3>O>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH:13]=[O:15])=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 4101HexamethylenetetramineHCID 785026-Nitro-1H-indole

생성물 1

HCID 52100766-nitro-1H-indole-3-carbaldehyde수율 77%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
120 °C

실험 절차

6-Nitroindole (1.0 g, 6.2 mmol) was successively added with acetic acid (2.5 mL), water (5.0 mL), and hexamethylenetetramine (1.2 g, 8.4 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration, and then dried to obtain 6-nitro-1H-indole-3-carboxaldehyde (0.91 g, 77%).

후처리

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried

출처 및 근거

ORD 기록
ord-716b45a55ff14e2fafb06dc475b3bfe6
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156827B2

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