Acetic Acid → 6-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
반응식
[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[C:11](O)(=[O:13])C.C1N2CN3CN(C2)CN1C3>O>[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([CH:11]=[O:13])[C:5]2=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 120 °C
실험 절차
6-Bromo-1H-pyrrolo[2,3-b]pyridine (0.028 g, 0.14 mmol) was successively added with acetic acid (0.1 mL), water (0.2 mL), and hexamethylenetetramine (0.028 g, 0.20 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration to obtain 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.008 g, 25%).
후처리
- filtrationthe precipitated solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-54e04f4ed5f144b7826a660df3b6b91a
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156827B2
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