Acetic Acid → 6-Methyl-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde

HRID 1749811노트

반응식

HRID 1749811 반응식
[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[C:11](O)(=[O:13])C.C1N2CN3CN(C2)CN1C3>O>[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([CH:11]=[O:13])[C:5]2=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 4101HexamethylenetetramineHCID 114577166-Methyl-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 247295536-Methyl-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde수율 67%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
120 °C

실험 절차

6-Methyl-1H-pyrrolo[2,3-b]pyridine (0.066 g, 0.50 mmol) was successively added with acetic acid (0.2 mL), water (0.4 mL), and hexamethylenetetramine (0.098 g, 0.70 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and then the precipitated solid was collected by filtration to obtain 6-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.054 g, 67%).

후처리

  1. filtrationthe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-c33c572ec4ca43839d20afa4e0002597
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156827B2

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