Potassium Carbonate → 7-Methylbenzofuran-3(2H)-one
반응식
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[OH:12])=[O:4].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:11][C:7]1[C:6]2[O:12][CH2:2][C:3](=[O:4])[C:5]=2[CH:10]=[CH:9][CH:8]=1참가 물질
4
실험 절차
A solution of 2-chloro-1-(2-hydroxy-3-methylphenyl)ethanone (Tetrahedron, Vol. 66, p. 3499, 2010, 6.40 g, 34.7 mmol) in acetonitrile (170 mL) was added with potassium carbonate (14.4 g, 104 mmol), and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain 7-methylbenzofuran-3(2H)-one (2.23 g, 43%).
후처리
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-0651c0a9ffae4ffb951324e378b3c85f
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156827B2
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