HCID 178520033, 화합물 → HCID 178520032, 화합물

HRID 1749865

반응식

HRID 1749865 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH2:11][OH:12]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH:11]=[O:12]

참가 물질

4

반응물 1

HCID 178520033HCID 178520033, 화합물

생성물 1

HCID 178520032HCID 178520032, 화합물수율 70.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of (5-fluoro-1H-indazol-3-yl)methanol (0.215 g, 1.29 mmol) in ethyl acetate (10 mL) was added with manganese dioxide (1.12 g, 12.9 mmol), and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, then the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 5-fluoro-1H-indazole-3-carbaldehyde (0.150 g, 70%).

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)

출처 및 근거

ORD 기록
ord-6d2bea766d1d4247a844bb381000f9b8
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156827B2

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