HCID 178520030, 화합물 → 5-chloro-1H-indazole-3-carbaldehyde
반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH2:11][OH:12]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH:11]=[O:12]참가 물질
4
실험 절차
A solution of (5-chloro-1H-indazol-3-yl)methanol (0.208 g, 1.14 mmol) in ethyl acetate (10 mL) was added with manganese dioxide (0.991 g, 11.4 mmol), and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, then the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 5-chloro-1H-indazole-3-carbaldehyde (0.106 g, 51%).
후처리
- filtrationThe reaction mixture was filtered through Celite
- concentrationthe filtrate was concentrated
- customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)
출처 및 근거
- ORD 기록
- ord-d0874be4f7f54238a129321dc68e4fcb
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156827B2
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