참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 4-Bromoanisole | HCID 7730 | — |
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 생성물 | HCID 178418276 | HCID 178418276 | — |
반응 단계
Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05726315 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-f12406699295447fa245b2a1d83d7703 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
