Water → 5-(Trifluoromethyl)-2-pyridinesulfonyl chloride

HRID 1750027노트

반응식

[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](S)=[N:7][CH:8]=1.[Cl:12][O-].[Na+].O.[OH:16][S:17]([OH:20])(=O)=O>>[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([S:17]([Cl:12])(=[O:20])=[O:16])=[N:7][CH:8]=1

참가 물질

반응물 4

HCID 962Water

HCID 1118Sulfuric Acid

HCID 23665760Sodium Hypochlorite

HCID 178506226HCID 178506226, 화합물

생성물 1

HCID 117469095-(Trifluoromethyl)-2-pyridinesulfonyl chloride수율 79%

실험 절차

0.8 g (4.47 mmol) of 5-trifluoromethyl-pyridine-2-thiol is placed at −8° C. in 16 mL of H2SO4. 16.96 mL (35.7 mmol) of a 13% sodium hypochlorite solution is poured gently such that the temperature of the reaction medium does not exceed 5° C. This mixture is then stirred for 45 min, taken up by water and then extracted using AcOEt. After drying followed by reduction to dryness of the organic phases, an oil is isolated (yield: 79%) and used as such for the next reactions.

후처리

customdoes not exceed 5° C
extractionextracted
customAfter drying
customan oil is isolated (yield: 79%)

출처 및 근거

ORD 기록: ord-7de90a654fc241a386f0d5b3fb366b36
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09156834B2

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