2-Morpholinoethylamine → 2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-(2-morpholin-4-ylethyl)-1,3-thiazole-4-carboxamide

HRID 1750367노트

반응식

HRID 1750367 반응식
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([C:22]([OH:24])=O)[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[O:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][NH2:33])[CH2:27][CH2:26]1>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([C:22]([NH:33][CH2:32][CH2:31][N:28]3[CH2:29][CH2:30][O:25][CH2:26][CH2:27]3)=[O:24])[N:21]=2)[CH:7]=[N:6]1)([CH3:3])([CH3:4])[CH3:2]

참가 물질

3

반응물 2

HCID 4082852-MorpholinoethylamineHCID 867212022-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazole-4-carboxylic acid

생성물 1

HCID 867212062-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-(2-morpholin-4-ylethyl)-1,3-thiazole-4-carboxamide

실험 절차

Using 2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazole-4-carboxylic acid and 2-morpholinoethanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

후처리

  1. customby reaction and purification in the same manner as in the method

출처 및 근거

ORD 기록
ord-a2fbec3857814bf48e8f9fe4d9ea8fce
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156837B2

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