5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one → 6-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

HRID 1750452노트

반응식

HRID 1750452 반응식
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22](O)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:25]1[C:34]2[CH2:33][CH2:32][NH:31][CH2:30][C:29]=2[CH:28]=[CH:27][C:26]1=[O:35]>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22]([N:31]3[CH2:32][CH2:33][C:34]4[NH:25][C:26](=[O:35])[CH:27]=[CH:28][C:29]=4[CH2:30]3)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:2])([CH3:4])[CH3:3]

참가 물질

3

반응물 2

HCID 210711895,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-oneHCID 867212902-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid

생성물 1

HCID 712507616-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

실험 절차

Using 2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid and 5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

후처리

  1. customby reaction and purification in the same manner as in the method

출처 및 근거

ORD 기록
ord-564983da2cb248ba84f5fb347a8c730e
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156837B2

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