3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid → 3-(2H-1,2,3-Triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]pyridine-2-carboxamide

HRID 1750666

반응식

HRID 1750666 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([N:27]2[N:31]=[CH:30][CH:29]=[N:28]2)=[C:6](C=1)[C:7]([NH:9][C@H:10]1[CH2:14][CH2:13][CH2:12][C@@H:11]1[NH:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=1)=[O:8].Cl.FC(F)(F)C1C=CC(N[C@H]2CCC[C@@H]2N)=[N:39]C=1.N1N(C2C(C(O)=O)=NC=CC=2)N=CC=1>>[N:28]1[N:27]([C:5]2[C:6]([C:7]([NH:9][C@H:10]3[CH2:14][CH2:13][CH2:12][C@@H:11]3[NH:15][C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:23])[F:24])=[CH:18][N:17]=3)=[O:8])=[N:39][CH:2]=[CH:3][CH:4]=2)[N:31]=[CH:30][CH:29]=1

참가 물질

4

반응물 3

HCID 667422883-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acidHCID 1183080695-Chloro-2-(2H-1,2,3-triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]benzamideHCID 118308256HCID 118308256, 화합물2회

생성물 1

HCID 1183082263-(2H-1,2,3-Triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]pyridine-2-carboxamide

실험 절차

Prepared according to the procedure for 5-chloro-2-(2H-1,2,3-triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]benzamide (Example 97) from (1S,2S)-1-N-[5-(trifluoromethyl)pyridin-2-yl]cyclopentane-1,2-diamine hydrochloride (Intermediate 1; 50 mg, 0.20 mmol) and 3-(2H-1,2,3-triazol-2-yl)pyridine-2-carboxylic acid (CAS number 1252907-86-0; 39 mg, 0.20 mmol) to afford the title compound.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3234cb1f51ee4aec901322d8b4c56313
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156829B2

연결된 노트

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