3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid → N-[(1S,2S)-2-{[3-Ethyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]-3-(2H-1,2,3-triazol-2-yl)pyridine-2-carboxamide

반응식

ClC1C(N[C@H]2CCC[C@@H]2N[C:19]([C:21]2[C:26]([N:27]3[N:31]=[CH:30][CH:29]=[N:28]3)=[CH:25][CH:24]=[CH:23][N:22]=2)=[O:20])=NC=C(C(F)(F)F)C=1.Cl.[CH2:33]([C:35]1[C:36]([NH:45][C@H:46]2[CH2:50][CH2:49][CH2:48][C@@H:47]2[NH2:51])=[N:37][CH:38]=[C:39]([C:41]([F:44])([F:43])[F:42])[N:40]=1)[CH3:34].N1N(C2C(C(O)=O)=NC=CC=2)N=CC=1>>[CH2:33]([C:35]1[C:36]([NH:45][C@H:46]2[CH2:50][CH2:49][CH2:48][C@@H:47]2[NH:51][C:19]([C:21]2[C:26]([N:27]3[N:31]=[CH:30][CH:29]=[N:28]3)=[CH:25][CH:24]=[CH:23][N:22]=2)=[O:20])=[N:37][CH:38]=[C:39]([C:41]([F:44])([F:42])[F:43])[N:40]=1)[CH3:34]