홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2-Iodobenzylic alcohol → 2-(4-Chlorophenyl)benzyl alcohol

HRID 1750740
노트
인쇄 미리보기

반응식

HRID 1750740 반응식
I[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[Cl:10][C:11]1[CH:16]=[CH:15][C:14](C2C=CC=CC=2B(O)O)=[CH:13][CH:12]=1>C([O-])([O-])=O.[Na+].[Na+].O1CCOCC1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH2:4][OH:5])=[CH:13][CH:12]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 1076292-Iodobenzylic alcoholHCID 234509984'-Chlorobiphenyl-2-boronic acid

생성물 1

HCID 13927802-(4-Chlorophenyl)benzyl alcohol

시약·촉매·용매 3

HCID 44119782Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)촉매HCID 10340Sodium Carbonate용매
HCID 31275
1,4-Dioxane
용매

반응 조건

온도
80 °C

실험 절차

A mixture of 2-iodobenzyl alcohol (11.0 g), 4-chlorophenylbenzeneboronic acid (8.5 g), and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (800 mg) in Na2CO3 (2M solution, 94 mL) and dioxane (300 mL) was heated to 80° C. for 24 hours. The mixture was cooled, the layers were separated, and the organic layer was condensed. The resulting residue was purified by silica gel chromatography eluting with 20% ethyl acetate in hexanes to give the desired product.

후처리

  1. temperatureThe mixture was cooled
  2. customthe layers were separated
  3. customcondensed
  4. customThe resulting residue was purified by silica gel chromatography
  5. washeluting with 20% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-7ee65dd410d74e2ab8bb4295062cb0ae
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09156856B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트