Pyridine → N-(1,3-dibromodibenzo[b,d]furan-4-yl)acetamide

HRID 1750917노트

반응식

HRID 1750917 반응식
[Br:1][C:2]1[C:10]2[C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[O:7][C:6]=2[C:5]([NH2:15])=[C:4]([Br:16])[CH:3]=1.N1C=CC=CC=1.[C:23](Cl)(=[O:25])[CH3:24]>ClCCl>[Br:1][C:2]1[C:10]2[C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[O:7][C:6]=2[C:5]([NH:15][C:23](=[O:25])[CH3:24])=[C:4]([Br:16])[CH:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 584010661,3-Dibromodibenzo[b,d]furan-4-amine

생성물 1

HCID 58400857N-(1,3-dibromodibenzo[b,d]furan-4-yl)acetamide수율 70.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a 2 L round-bottomed flask, 1,3-dibromodibenzo[b,d]furan-4-amine (76 g, 223 mmol) in dichloromethane (800 mL) and pyridine (180 mL, 2229 mmol) were cooled by ice bath. Acetyl chloride (31.7 mL, 446 mmol) was added dropwise while stirring. Then the ice bath was removed. The reaction was stirred at room temperature for 1 h. The residue was collected by filtration and washed by water and dichloromethane to give N-(1,3-dibromodibenzo[b,d]furan-4-yl)acetamide (60 g, 70.3% yield) as brown solid.

후처리

  1. customThen the ice bath was removed
  2. stirringThe reaction was stirred at room temperature for 1 h
  3. filtrationThe residue was collected by filtration
  4. washwashed by water and dichloromethane

출처 및 근거

ORD 기록
ord-61240f818c4c40c08651ddf6cc23109d
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156870B2

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