2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide → N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

HRID 17510노트

반응식

HRID 17510 반응식
C([O:8][CH2:9][C:10]([NH:12][C:13]1[C:18]([C:19]#[N:20])=[C:17]([CH3:21])[C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([F:28])[C:14]=1[OH:29])=[O:11])C1C=CC=CC=1>[C].[Pd].C(O)C>[C:19]([C:18]1[C:13]([NH:12][C:10](=[O:11])[CH2:9][OH:8])=[C:14]([OH:29])[C:15]([F:28])=[C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:17]=1[CH3:21])#[N:20]

참가 물질

4

반응물 1

HCID 866308382-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide

생성물 1

HCID 86630863N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A catalyst 10%-palladium carbon (40.0 mg) was added to an ethanol (10 ml) solution of 2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide (I-89) (120 mg, 0.307 mmol), followed by stirring under hydrogen atmosphere at room temperature for 15 hours. After the reaction, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the entitled compound. Not purified, this was used in the next reaction as such.

후처리

  1. customAfter the reaction
  2. customthe insoluble matter was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customto obtain the entitled compound
  5. customNot purified
  6. customthis was used in the next reaction as such

출처 및 근거

ORD 기록
ord-648b7b07cd4b472093af3e33c292ca65
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

반응 노트

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