Morpholine → HCID 58855409, 화합물

HRID 1751315노트

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HRID 1751315 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]([F:24])([C:15]([F:23])([F:22])[C:16]([F:21])([F:20])[CH:17]([F:19])[F:18])[CH2:9][O:10][CH2:11][CH:12]1[O:14][CH2:13]1>>[O:4]1[CH2:5][CH2:6][N:1]([CH2:13][CH:12]([OH:14])[CH2:11][O:10][CH2:9][C:8]([F:7])([F:24])[C:15]([F:22])([F:23])[C:16]([F:21])([F:20])[CH:17]([F:19])[F:18])[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 27758863-(1h,1h,5h-Octafluoropentyloxy)-1,2-epoxypropane

생성물 1

HCID 58855409HCID 58855409, 화합물수율 89.1%

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온도
80 °C

실험 절차

To 8.7 g of morpholine was added dropwise 28.8 g of glycidyl 2,2,3,3,4,4,5,5-octafluoropentyl ether. The mixture was then stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography. There was obtained 33.4 g of 1-morpholino-3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-2-propanol (yield 89%).

후처리

  1. customThe reaction mixture was directly purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-f2d8bde5aac24984aa97e247b4bbb597
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09158191B2

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