4-Bromophenacyl bromide → HCID 69673289, 화합물

HRID 1751335노트

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HRID 1751335 반응식
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][C@H:9]1[C:17]([OH:19])=[O:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=1)=[O:23].CCN(CC)CC>CC#N.CCOC(C)=O.C([O-])(O)=O.[Na+].[Cl-].[Na+].O>[N:8]1([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][C@H:9]1[C:17]([O:19][CH2:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=1)=[O:23])=[O:18]

참가 물질

8

반응물 3

HCID 74544-Bromophenacyl bromideHCID 8471TriethylamineHCID 2755955(2S)-1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-2-carboxylic acid

생성물 1

HCID 69673289HCID 69673289, 화합물

시약·촉매·용매 4

HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매HCID 516892Sodium Bicarbonate용매HCID 57417360Sodium chloride; water용매

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온도
55 °C

실험 절차

To a solution of (S)-1-(tert-butoxycarbonyl)indoline-2-carboxylic acid (1.61 g, 6.11 mmol) and 2-bromo-1-(4-bromophenyl)ethanone (2.55 g, 9.17 mmol) in MeCN (25 mL) was added Et3N (1.27 mL, 9.17 mmol). The solution was heated to 55° C. and stirred o/n. The solution was cooled to rt, diluted with EtOAc, sat. NaHCO3, brine, dried with MgSO4, and concentrated. The residue was taken onto the next step crude.

후처리

  1. temperatureThe solution was cooled to rt
  2. dry with materialdried with MgSO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-066fd6372ed14d02b08e01ff46a81305
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156823B2

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