Potassium Carbonate → (S)-tert-butyl 2-(5-(4-(6-(2-((S)-1-((2S,3R)-3-(difluoromethoxy)-2-(methoxycarbonylamino)butanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

반응식

[F:1][CH:2]([F:43])[O:3][C@H:4]([CH3:42])[C@H:5]([NH:37][C:38](=[O:41])[O:39][CH3:40])[C:6](=[O:36])[N:7]1[CH2:11][CH2:10][CH2:9][C@H:8]1[C:12]1[NH:13][C:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22](B4OC(C)(C)C(C)(C)O4)[CH:23]=3)[CH:18]=2)=[CH:15][N:16]=1.Br[C:45]1[CH:50]=[CH:49][C:48]([C:51]2[NH:55][C:54]([C@@H:56]3[CH2:60][CH2:59][CH2:58][N:57]3[C:61]([O:63][C:64]([CH3:67])([CH3:66])[CH3:65])=[O:62])=[N:53][CH:52]=2)=[CH:47][CH:46]=1.C(=O)([O-])[O-].[K+].[K+]>C(COC)OC>[F:1][CH:2]([F:43])[O:3][C@H:4]([CH3:42])[C@H:5]([NH:37][C:38]([O:39][CH3:40])=[O:41])[C:6]([N:7]1[CH2:11][CH2:10][CH2:9][C@H:8]1[C:12]1[NH:13][C:14]([C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[CH:23]=[C:22]([C:45]2[CH:46]=[CH:47][C:48]([C:51]4[NH:55][C:54]([C@@H:56]5[CH2:60][CH2:59][CH2:58][N:57]5[C:61]([O:63][C:64]([CH3:67])([CH3:66])[CH3:65])=[O:62])=[N:53][CH:52]=4)=[CH:49][CH:50]=2)[CH:21]=[CH:20]3)=[CH:15][N:16]=1)=[O:36]