Potassium Carbonate → tert-butyl 3-(6-(3-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[c]chromen-8-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

반응식

[CH3:1][CH:2]([CH3:44])[CH:3]([NH:39][C:40](=[O:43])[O:41][CH3:42])[C:4](=[O:38])[N:5]1[CH2:9][CH2:8][CH2:7][C@H:6]1[C:10]1[NH:11][C:12]([C:15]2[CH:24]=[C:23]3[C:18]([C:19]4[CH:28]=[CH:27][C:26](B5OC(C)(C)C(C)(C)O5)=[CH:25][C:20]=4[CH2:21][O:22]3)=[CH:17][CH:16]=2)=[CH:13][N:14]=1.Br[C:46]1[CH:47]=[CH:48][C:49]2[N:53]=[C:52]([C@@H:54]3[C@@H:59]4[CH2:60][C@@H:56]([CH2:57][CH2:58]4)[N:55]3[C:61]([O:63][C:64]([CH3:67])([CH3:66])[CH3:65])=[O:62])[NH:51][C:50]=2[CH:68]=1.C(=O)([O-])[O-].[K+].[K+]>COCCOC.CN(C)C=O.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[CH3:42][O:41][C:40]([NH:39][C@@H:3]([CH:2]([CH3:44])[CH3:1])[C:4]([N:5]1[CH2:9][CH2:8][CH2:7][C@H:6]1[C:10]1[NH:11][C:12]([C:15]2[CH:24]=[C:23]3[C:18]([C:19]4[CH:28]=[CH:27][C:26]([C:47]5[CH:46]=[CH:68][C:50]6[N:51]=[C:52]([CH:54]7[C@@H:59]8[CH2:60][CH:56]([CH2:57][CH2:58]8)[N:55]7[C:61]([O:63][C:64]([CH3:66])([CH3:65])[CH3:67])=[O:62])[NH:53][C:49]=6[CH:48]=5)=[CH:25][C:20]=4[CH2:21][O:22]3)=[CH:17][CH:16]=2)=[CH:13][N:14]=1)=[O:38])=[O:43].[CH3:42][O:41][C:40]([NH:39][C@@H:3]([CH:2]([CH3:44])[CH3:1])[C:4]([N:5]1[CH2:9][CH2:8][CH2:7][C@H:6]1[C:10]1[NH:11][C:12]([C:15]2[CH:24]=[C:23]3[C:18]([C:19]4[CH:28]=[CH:27][C:26]([C:47]5[CH:46]=[CH:68][C:50]6[N:51]=[C:52]([CH:54]7[CH:59]8[CH2:60][CH:56]([CH2:57][CH2:58]8)[N:55]7[C:61]([O:63][C:64]([CH3:66])([CH3:65])[CH3:67])=[O:62])[NH:53][C:49]=6[CH:48]=5)=[CH:25][C:20]=4[CH2:21][O:22]3)=[CH:17][CH:16]=2)=[CH:13][N:14]=1)=[O:38])=[O:43]