tert-Butoxy bis(dimethylamino)methane → (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 1751400노트

반응식

HRID 1751400 반응식
C(O[CH:6]([N:10]([CH3:12])[CH3:11])N(C)C)(C)(C)C.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[O:22])[CH3:21])=[C:16]([OH:23])[CH:15]=1>C1(C)C=CC=CC=1>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[O:22])/[CH:21]=[CH:6]/[N:10]([CH3:11])[CH3:12])=[C:16]([OH:23])[CH:15]=1

참가 물질

4

반응물 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 107274031-(4-Bromo-2-hydroxyphenyl)ethan-1-one

생성물 1

HCID 11737295(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one수율 82.8%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 1-tert-Butoxy-N,N,N′,N′-tetramethylmethanediamine (19.2 mL, 93.0 mmol) and solution of 1-(4-bromo-2-hydroxyphenyl)ethanone (10 g, 46.5 mmol) in toluene (100 mL) was heated at 35° C. for 16 hours and at 80° C. for 1 hour. The solvent was removed under reduced pressure. The resulting solid was subjected to flash chromatography with eluant of dichloromethane. The product containing fractions were combined and the solvent was removed under reduced pressure to provide (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one (10.4 g, 38.5 mmol, 82%).

후처리

  1. customThe solvent was removed under reduced pressure
  2. additionThe product containing fractions
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-239362f861f843d697b25c49b54be952
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156823B2

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