Potassium Carbonate → HCID 69675721, 화합물

HRID 1751410노트

반응식

HRID 1751410 반응식
[CH3:1][O:2][C:3](=[O:43])[NH:4][CH:5]([CH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1)[C:6](=[O:36])[N:7]1[CH2:11][CH2:10][CH2:9][CH:8]1[C:12]1[NH:13][C:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22](B4OC(C)(C)C(C)(C)O4)[CH:23]=3)[CH:18]=2)=[CH:15][N:16]=1.[C:44]([O:48][C:49](=[O:61])[NH:50][CH2:51][C:52]([C:54]1[CH:59]=[CH:58][C:57](Br)=[CH:56][CH:55]=1)=[O:53])([CH3:47])([CH3:46])[CH3:45].C(=O)([O-])[O-].[K+].[K+]>COCCOC.O.[Cl-].[Na+].O>[CH3:1][O:2][C:3](=[O:43])[NH:4][CH:5]([CH:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1)[C:6]([N:7]1[CH2:11][CH2:10][CH2:9][CH:8]1[C:12]1[NH:13][C:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:57]4[CH:58]=[CH:59][C:54]([C:52](=[O:53])[CH2:51][NH:50][C:49]([O:48][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:61])=[CH:55][CH:56]=4)[CH:23]=3)[CH:18]=2)=[CH:15][N:16]=1)=[O:36]

참가 물질

7

반응물 3

HCID 11430Potassium CarbonateHCID 59610197tert-butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamateHCID 69675202[2-Oxo-1-(tetrahydro-pyran-4-yl)-2-(2-{5-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalen-2-yl]-1H-imidazol-2-yl}-pyrrolidin-1-yl)-ethyl]-carbamic acid methyl ester

생성물 1

HCID 69675721HCID 69675721, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 80711,2-Dimethoxyethane용매HCID 57417360Sodium chloride; water용매

실험 절차

[2-Oxo-1-(tetrahydro-pyran-4-yl)-2-(2-{5-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalen-2-yl]-1H-imidazol-2-yl}-pyrrolidin-1-yl)-ethyl]-carbamic acid methyl ester (200 mg, 0.34 mmol), [2-(4-Bromo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (106 mg, 0.34 mmol), Pd[PPh3]4 (39.2 mg, 0.034 mmol), potassium carbonate (117 mg, 0.85 mmol) was heated at 120 C in the microwave for 22 minutes in DME (2.5 mL) and water (0.3 mL). Brine (1 mL) was added and the organic layer was isolated and the volatiles were removed. The product was purified via flash chromatography on silica gel (eluent: EtOAc/hexanes) to yield 183 mg.

후처리

  1. customthe organic layer was isolated
  2. customthe volatiles were removed
  3. customThe product was purified via flash chromatography on silica gel (eluent: EtOAc/hexanes)
  4. customto yield 183 mg

출처 및 근거

ORD 기록
ord-ad3a86b403ba406aa39a4c09ab303399
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156823B2

반응 노트

불러오는 중…