Formic Acid → (R)-1-(3-Chlorophenyl)ethanol
반응식
C([O-])=O.[K+].C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1>[Ru].CO>[Cl:8][C:9]1[CH:10]=[C:11]([C@H:15]([OH:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1참가 물질
6
반응 조건
- 온도
- 50 °C
실험 절차
A ruthenium complex RuCl[(R,R)-Tsdpen] (mesitylene) (2.1 mg, 0.0033 mmol), potassium formate (1.0 g, 12 mmol), formic acid (138 mg, 3 mmol) and 3′-chloroacetophenone (1.55 g, 10 mmol, substrate/catalyst ratio=3000) were set in a 20 mL glass Schlenk-type reaction tube under an argon atmosphere. Methanol (6 mL) was added thereto and stirred at 50° C. for 24 hours to give (R)-1-(3′-chlorophenyl)ethanol at 100% yield and 96.5% ee optical purity.
출처 및 근거
- ORD 기록
- ord-c069fcffd9ad4384ad4742a821f2db62
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09162934B2
반응 노트
불러오는 중…