Pyrazole → 1-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOLE

HRID 1751925노트

반응식

HRID 1751925 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.Cl[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1>>[F:14][C:13]([F:16])([F:15])[C:10]1[CH:11]=[CH:12][C:7]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)=[CH:8][CH:9]=1

참가 물질

3

반응물 2

HCID 1048PyrazoleHCID 73941-Chloro-4-(trifluoromethyl)benzene

생성물 1

HCID 112180941-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOLE

실험 절차

Following General Procedure A (140° C., 24 hours), 1H-pyrazole (102 mg, 1.5 mmol) is coupled with 1-chloro-4-(trifluoromethyl)benzene (134 μL, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 80 mg (38% isolated yield) of the desired product as a white solid.

후처리

  1. customThe crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50)
  2. customto provide

출처 및 근거

ORD 기록
ord-b8c3e9a1055949e8986ee55e31a19680
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09162953B2

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