Tert-butyl 3-(4-methylthiazol-2-yl)pyrrolidine-1-carboxylate → 4-Methyl-2-(pyrrolidin-3-yl)-1,3-thiazole

HRID 1752303노트

반응식

HRID 1752303 반응식
[CH3:1][C:2]1[N:3]=[C:4]([CH:7]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]2)[S:5][CH:6]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH3:1][C:2]1[N:3]=[C:4]([CH:7]2[CH2:11][CH2:10][NH:9][CH2:8]2)[S:5][CH:6]=1

참가 물질

3

반응물 1

HCID 23532020Tert-butyl 3-(4-methylthiazol-2-yl)pyrrolidine-1-carboxylate

생성물 1

HCID 121500044-Methyl-2-(pyrrolidin-3-yl)-1,3-thiazole수율 98%

시약·촉매·용매 1

HCID 21863450Trifluoroacetic acid methylene chloride용매

실험 절차

To a solution of tert-butyl 3-(4-methylthiazol-2-yl)pyrrolidine-1-carboxylate (90 mg, 0.34 mmol) in TFA/CH2Cl2 (20%, 2 mL) was stirred at rt for 1 h and concentrated to give 4-methyl-2-(pyrrolidin-3-yl)thiazole (55 mg, 98%) as a yellow oil.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-69cb5bceaa324528bb9a306dc7a86425
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163012B2

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