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Acetic Acid → (R)-3-(6-Bromo-3-fluoro-pyridin-2-yl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester

HRID 1752457
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HRID 1752457 반응식
[F-].[K+].[CH2:3]([O:5][C:6](=[O:34])[C:7]([F:33])([F:32])[C@@:8]([C:17]1[C:22]([F:23])=[C:21]([Si](CC)(CC)CC)[CH:20]=[C:19]([Br:31])[N:18]=1)([NH:10][S@@:11]([C:13]([CH3:16])([CH3:15])[CH3:14])=[O:12])[CH3:9])[CH3:4].C(O)(=O)C.CN(C=O)C>C1COCC1.C(OCC)(=O)C>[CH2:3]([O:5][C:6](=[O:34])[C:7]([F:32])([F:33])[C@@:8]([C:17]1[C:22]([F:23])=[CH:21][CH:20]=[C:19]([Br:31])[N:18]=1)([NH:10][S@@:11]([C:13]([CH3:16])([CH3:14])[CH3:15])=[O:12])[CH3:9])[CH3:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 6228DimethylformamideHCID 522689Potassium FluorideHCID 86689143(R)-3-(6-bromo-3-fluoro-4-triethylsilanyl-pyridin-2-yl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester

생성물 1

HCID 86689142(R)-3-(6-Bromo-3-fluoro-pyridin-2-yl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester
수율 88%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

Freshly ground KF (195 mg, 3.36 mmol) was added to a solution of (R)-3-(6-bromo-3-fluoro-4-triethylsilanyl-pyridin-2-yl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester (940 mg, 1.68 mmol) and acetic acid (0.192 ml, 3.36 mmol) in THF (7 ml). DMF (7 ml) was added and the suspension was stirred at rt. After 2 h the reaction mixture was diluted with ethyl acetate and washed with sat. sodium bicarbonate solution and brine, dried over sodium sulfate, filtered and evaporated. The crude product (733 mg) was chromatographed over silica gel (cyclohexane/ethyl acetate 7:3) to give the title compound as a slightly yellow oil. 664 mg (88% yield).

후처리

  1. washwashed with sat. sodium bicarbonate solution and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. customevaporated
  5. customThe crude product (733 mg) was chromatographed over silica gel (cyclohexane/ethyl acetate 7:3)

출처 및 근거

ORD 기록
ord-a8047e20f19b43c3910a9efe2e51bfec
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09163011B2

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