Tetrahydro-2-(2-propynyloxy)-2H-pyran → HCID 71271170, 화합물

HRID 1752490노트

반응식

HRID 1752490 반응식
C[O:2][C:3]([C:5]1[C:10]([Cl:11])=[CH:9][C:8](Br)=[CH:7][N:6]=1)=[O:4].[CH2:13]([O:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1)[C:14]#[CH:15]>>[Cl:11][C:10]1[C:5]([C:3]([OH:2])=[O:4])=[N:6][CH:7]=[C:8]([C:15]#[C:14][CH2:13][O:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)[CH:9]=1

참가 물질

3

반응물 2

HCID 98609Tetrahydro-2-(2-propynyloxy)-2H-pyranHCID 46311201Methyl 5-bromo-3-chloropyridine-2-carboxylate

생성물 1

HCID 71271170HCID 71271170, 화합물

실험 절차

The title compound was prepared by an analogous procedure to Acid-xx using 5-bromo-3-chloro-pyridine-2-carboxylic acid methyl ester instead of 3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester and 2-prop-2-ynyloxy-tetrahydro-pyran instead of 3-methoxy-propyne [Acid-xx step a)].

출처 및 근거

ORD 기록
ord-50b9e1549a714ceeb00f3978ea28c363
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163011B2

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