1,4-Dioxane hydrochloride → (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate

HRID 1752538

반응식

HRID 1752538 반응식
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([C@@H:18]2[CH2:22][CH2:21][CH2:20][N:19]2[C:23]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:24])=[O:17])=[CH:11][CH:10]=1)=O)(C)(C)C.O1CCOCC1.Cl>O1CCOCC1>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([C@@H:18]2[CH2:22][CH2:21][CH2:20][N:19]2[C:23]([O:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[O:24])=[O:17])=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59396122(S)-benzyl 2-(4-(tert-butoxycarbonylamino)phenylcarbamoyl)pyrrolidine-1-carboxylate

생성물 1

HCID 59396116(S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of the Product from Example 3A (0.245 g, 0.56 mmol) in dioxane (5 mL) was added 4M HCl dioxane (2.8 mL, 11.2 mol) and the mixture was stirred at ambient temperature for 17 hours. The mixture was concentrated and azeotroped with toluene to five a tan solid (0.18 g, 86%).

후처리

  1. concentrationThe mixture was concentrated
  2. customazeotroped with toluene to five a tan solid (0.18 g, 86%)

출처 및 근거

ORD 기록
ord-36f016a6f41b4814a42681bcb9c1d8d5
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163017B2

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