2-([1,2,4]Triazolo[1,5-a]pyridin-2-yl)ethanamine → 7-Chloro-5-methyl-2-(2-[1,2,4]triazolo[1,5-a]pyridin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione

반응식

[N:1]1[C:2]([CH2:10][CH2:11][NH2:12])=[N:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[CH3:13][N:14]1[CH:19]=[C:18]([C:20](O)=[O:21])[C:17]([C:23](OC)=[O:24])=[C:16]([Cl:27])[C:15]1=[O:28]>>[Cl:27][C:16]1[C:15](=[O:28])[N:14]([CH3:13])[CH:19]=[C:18]2[C:20](=[O:21])[N:12]([CH2:11][CH2:10][C:2]3[N:1]=[C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][N:4]4[N:3]=3)[C:23](=[O:24])[C:17]=12

참가 물질

반응물 2

HCID 712955522-([1,2,4]Triazolo[1,5-a]pyridin-2-yl)ethanamine

HCID 904220091-Methyl-2-oxo-1,2-dihydro-3-chloro-4-methoxycarbonyl-pyridine-5-carboxylic acid

생성물 1

HCID 904220267-Chloro-5-methyl-2-(2-[1,2,4]triazolo[1,5-a]pyridin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione

실험 절차

The title compound was prepared in analogy to the process described in Example c1) starting from 2-([1,2,4]triazolo[1,5-a]pyridin-2-yl)ethanamine and compound (4).

출처 및 근거

ORD 기록: ord-460df8075b9545ff9307431e9f4939c2
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09163019B2

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