반응식
[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]2[N:14]=[C:13]([NH2:15])[NH:12][N:11]=2)=[CH:4][CH:3]=1.[F:18][CH:19]([F:28])[C:20](=O)[CH2:21][C:22](=O)[CH:23]([F:25])[F:24].ClC1C=CC(OCCCC2N=C(N)NN=2)=CC=1.FC1C=CC(O)=CC=1>>[F:18][CH:19]([F:28])[C:20]1[CH:21]=[C:22]([CH:23]([F:25])[F:24])[N:12]2[N:11]=[C:10]([CH2:9][CH2:8][CH2:7][O:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=3)[N:14]=[C:13]2[N:15]=1.[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]2[N:14]=[C:13]([NH2:15])[NH:12][N:11]=2)=[CH:16][CH:17]=1참가 물질
6
반응물 4
생성물 2
실험 절차
The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 1,1,5,5-tetrafluoropentane-2,4-dione in 72% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. 1H NMR (DMSO-d6, 400 MHz) δ ppm: 7.83 (s, 1H), 7.63 (t, 1H), 7.18 (t, 1H), 7.09 (m, 2H), 6.95 (m, 2H), 4.08 (t, 2H), 3.11 (t, 2H), 2.24 (m, 2H).
출처 및 근거
- ORD 기록
- ord-b836ab28fa234825b8fabc591f498313
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09163027B2
연결된 노트
불러오는 중…