Isopropyl iodide → HCID 90093605, 화합물

HRID 1753056노트

반응식

[Br:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[C:10]([F:11])[C:5]=2[NH:4][CH:3]=1.I[CH:13]([CH3:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[C:10]([F:11])[C:5]=2[N:4]([CH:13]([CH3:15])[CH3:14])[CH:3]=1

참가 물질

반응물 3

HCID 6362Isopropyl iodide

HCID 11430Potassium Carbonate

HCID 534126073-bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine

생성물 1

HCID 90093605HCID 90093605, 화합물수율 56%

실험 절차

Prepared according to the method described for Preparation 45 using 3-bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine (Preparation 48), 2-iodopropane and potassium carbonate as base. Purified using silica gel column chromatography eluting with 100% heptanes to 50:50 Heptane:EtOAc to afford the title compound (845 mg, 56%).

후처리

customPrepared
customPurified
washeluting with 100% heptanes to 50:50 Heptane

출처 및 근거

ORD 기록: ord-651c583086984c52905f0f248aae33ea
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09163021B2

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