Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → Ethyl ethoxymethylene-3-oxo-4,4,4-trifluorobutyrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| 생성물 | Ethyl ethoxymethylene-3-oxo-4,4,4-trifluorobutyrate | HCID 6185754 | 96.4% |
반응 단계
4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (16 g, 86.4 mmol) was dissolved in acetic anhydride (33.6 g, 329.6 mmol) and triethyl orthoformate (38.4 g, 260 mmol) was added to the mixture. The resultant mixture was refluxed for 18 hours. The mixture was concentrated under reduced pressure to obtain 20 g of 2-[1-Ethoxy-meth-(E)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester as crude.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09163021B2 |
| 출처 데이터셋 | uspto-grants-2015_10 |
| ORD ID | ord-c69bb7231c8f41809dd60e5b3613124d |
| 출처 메모 | uspto-grants-2015_10 |