Acetic Anhydride → Ethyl ethoxymethylene-3-oxo-4,4,4-trifluorobutyrate

HRID 1753087

반응식

HRID 1753087 반응식
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8])[CH3:2].[C:13]([O:16][C:17](=O)C)(=O)[CH3:14].C(OCC)(OCC)OCC>>[CH2:1]([O:3][C:4](=[O:12])/[C:5](=[CH:17]/[O:16][CH2:13][CH3:14])/[C:6](=[O:11])[C:7]([F:10])([F:8])[F:9])[CH3:2]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 67793Ethyl 4,4,4-trifluoroacetoacetate

생성물 1

HCID 6185754Ethyl ethoxymethylene-3-oxo-4,4,4-trifluorobutyrate수율 96.4%

실험 절차

4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (16 g, 86.4 mmol) was dissolved in acetic anhydride (33.6 g, 329.6 mmol) and triethyl orthoformate (38.4 g, 260 mmol) was added to the mixture. The resultant mixture was refluxed for 18 hours. The mixture was concentrated under reduced pressure to obtain 20 g of 2-[1-Ethoxy-meth-(E)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester as crude.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c69bb7231c8f41809dd60e5b3613124d
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163021B2

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