Thionyl Chloride → 6-(Chloromethyl)-N,N,5-trimethylpyrimidin-4-amine

HRID 1753216노트

반응식

HRID 1753216 반응식
[CH3:1][N:2]([CH3:12])[C:3]1[N:8]=[CH:7][N:6]=[C:5]([CH2:9]O)[C:4]=1[CH3:11].S(Cl)([Cl:15])=O>C(Cl)Cl>[Cl:15][CH2:9][C:5]1[N:6]=[CH:7][N:8]=[C:3]([N:2]([CH3:12])[CH3:1])[C:4]=1[CH3:11]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 14306168(6-(Dimethylamino)-5-methylpyrimidin-4-yl)methanol

생성물 1

HCID 143061696-(Chloromethyl)-N,N,5-trimethylpyrimidin-4-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (6-(dimethylamino)-5-methylpyrimidin-4-yl)methanol (24) (0.1 g, 0.60 mmol) in DCM was added thionyl chloride (0.14 g, 1.1961 mmol). The reaction mixture was stirred for 4 h at RT. The solvent was removed under reduced pressure to afford 6-(Chloromethyl)-N,N,5-trimethylpyrimidin-4-amine (25) as a white solid; 0.1 g 90.9%).

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-778f55ef666f4dd2991ec96859cde671
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163020B2

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