Dimethylformamide diethylacetal → 3-(Dimethylamino)-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]acrylic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[CH:7]1)[CH3:2].C(O[CH:19](OCC)[N:20]([CH3:22])[CH3:21])C>>[CH2:1]([O:3][C:4](=[O:15])[C:5]([N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:12])[F:13])[N:8]=[CH:7]1)=[CH:19][N:20]([CH3:22])[CH3:21])[CH3:2]참가 물질
3
실험 절차
38.0 g (170.8 mmol) of the compound from Example 32A and 58.5 ml (50.3 g, 341.6 mmol) dimethylformamide diethyl acetal are stirred at a bath temperature of 100° C. for 16 h. For working up, the cooled reaction solution is concentrated on a rotary evaporator and the residue is dried in vacuo.
후처리
- customthe cooled reaction solution
- concentrationis concentrated on a rotary evaporator
- customthe residue is dried in vacuo
출처 및 근거
- ORD 기록
- ord-297d59f3dcd64ef38d8b1e9b2ea6162d
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09168249B2
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