Ammonia → 3-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide

HRID 1753977노트

반응식

HRID 1753977 반응식
[Br:1][C:2]1[CH2:6][CH:5]([C:7]([O:9]CC)=O)[O:4][N:3]=1.[NH3:12]>CO>[Br:1][C:2]1[CH2:6][CH:5]([C:7]([NH2:12])=[O:9])[O:4][N:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 66696825Ethyl 3-bromo-4,5-dihydro-1,2-oxazole-5-carboxylate

생성물 1

HCID 441183083-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of ethyl 3-bromo-4,5-dihydroisoxazole-5-carboxylate (6.2 g, 28 mmol) and a solution of 2 M ammonia in MeOH (56 mL) was stirred at room temperature for 1 to 2 hours. Volatile materials were removed in vacuo to give the crude title compound as a white solid.

후처리

  1. customVolatile materials were removed in vacuo

출처 및 근거

ORD 기록
ord-d011d876bc284934b51899a00d1ca052
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09168248B2

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