Acetyl chloride → (S)-N-(1-(5-Hydroxypyridin-2-yl)ethyl)acetamide

HRID 1754058노트

반응식

HRID 1754058 반응식
[NH2:1][C@H:2]([C:4]1[N:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)[CH3:3].[C:11](Cl)(=[O:13])[CH3:12]>C1COCC1>[OH:10][C:7]1[CH:6]=[CH:5][C:4]([C@@H:2]([NH:1][C:11](=[O:13])[CH3:12])[CH3:3])=[N:9][CH:8]=1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 78960964HCID 78960964, 화합물

생성물 1

HCID 86687917(S)-N-(1-(5-Hydroxypyridin-2-yl)ethyl)acetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 1.00 g (5.73 mmol) (S)-6-(1-aminoethyl)pyridin-3-ol in 10 ml THF and 3.99 mL TEA (28.6 mmol) are slowly added 494 mg (6.30 mmol) acetyl chloride and stirring is continued for 2 h. The reaction is quenched by the addition of water and extracted several times with DCM. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, DCM/MeOH/NH3 90/9/1).

후처리

  1. customThe reaction is quenched by the addition of water
  2. extractionextracted several times with DCM
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed in vacuo
  6. customThe crude product is purified by column chromatography (silica gel, DCM/MeOH/NH3 90/9/1)

출처 및 근거

ORD 기록
ord-5b00ee20e45e4233b178b1bc903bf176
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169205B2

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